MODULATING MULTIPLE DRUG RESISTANCE VIA CO-DELIVERY OF NANOPARTICLE

Doxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance

With the extensive application of doxorubicin (DOX), DOX resistance has become one of the main obstacles to the effective treatment of breast cancer. In this paper, DOX and resveratrol (RES) were co-encapsulated in a modified PLGA nanoparticle (NPS) to overcome the DOX resistance. CLSM results indicated that DOX and RES were simultaneously delivered into the nucleus of DOX-resistant human breas...

Nanoparticle Technology for Drug Delivery

La tecnología de nanopartículas se espera que revolucione la manera en que se lleva a cabo la administración de fármacos. Las tecnologías de nanopartículas tienen la capacidad de mejorar la eficacia de los medicamentos, reducir al mínimo los efectos secundarios, y proporcionar una entrega específica, sólo para nombrar algunos. Con el fin de aprovechar las aplicaciones y ventajas de las nanopart...

Computational Modeling of Nanoparticle Targeted Drug Delivery

Nanomedicine is a promising application of nanotechnology in medicine, which can drastically improve drug delivery efficiency through targeted delivery. However, characterization of the nanoparticle targeted delivery process under vascular environment is very challenging due to the small scale of nanoparticles and the complex in vivo vascular system. To understand such complicated system, vario...

Aptamer-Nanoparticle Bioconjugates for Drug Delivery

Nanoparticle-Mediated Pulmonary Drug Delivery: A Review

Colloidal drug delivery systems have been extensively investigated as drug carriers for the application of different drugs via different routes of administration. Systems, such as solid lipid nanoparticles, polymeric nanoparticles and liposomes, have been investigated for a long time for the treatment of various lung diseases. The pulmonary route, owing to a noninvasive method of drug administr...